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KMID : 0356919930260061207
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Korean Journal of Anesthesiology
1993 Volume.26 No. 6 p.1207 ~ p.1213
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Comparative Study of Ondansetron versus Placebo to Prevent Postoperative Nausea and Vomiting in those Undergoing Abdominal Surgery
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김광민
김현수/최현/박순은/윤정배/최병조
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Abstract
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Postoperative emesis is still a troublesome problem in patients undergoing general anesthesia. We compared the efficacy and safety of ondansetron, a selective antagonist of serotonin 5HT3 receptors, within the 24hours postoperative period.
Forty patients between the ages of 12 and 75 ASA class I-III, having general anesthesia, undergoing elective abdominal surgery (except gynecologic surgery) were assigned to one of two treatment groups according to uncontrolled parallel
comparative
study
design. A standard anesthetic technique consisting of thiopental-atracurium for induction and N2O-Enflurane for maintenance of anesthesia was used.
The data showed that intravenous ondansetron 4mg i.v. before induction was significantly more effective in preventing emesis (n=20, 85%) than placebo (n=20, 60%). Nausea severity score were also significantly decreased from 1.5.±0.6 (mean±SE)
in
placebo group to 0.3±0.1 in ondansetron group (P<0.05). All patients receiving of ondansetron 4mg intravenously tolerated their treatment well, without any special adverse events.
Conclusion: Ondansetron(4mg) given intravenously before induction to prevent postoperative nausea and vomiting in patients undergoing elective abdominal surgery was effective and safe.
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KEYWORD
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